| Foxp3+/Foxp3− Treg |
Variety |
Foxp3+… or Foxp3−… |
Variety |
|
CD4+/CD8+ Treg7
|
Variety |
CD4+Foxp3+/−… or CD8+Foxp3+/−… |
Variety |
|
NKTreg and γδ-Treg8
|
Variety |
Markers of NKT or γδ-T cells |
IL-10/TGF-β |
|
nTreg/iTreg9
|
| nTreg (natural Treg) |
In thymus |
CD4+Foxp3+CD25int/hi, CD127loCTLA4+GITR+
|
IL-10/TGF-βDirect contactGranzyme B |
| iTreg (induced Treg) |
| Tr1 |
In periphery |
CD4+Foxp3−CD25−, CD25lo-varCD45RBlo
|
IL-10 |
| Th3 |
In periphery |
CD4+Foxp3+CD25+, CD25lo-varCD45RBlo
|
TGF-β |
|
tTreg/pTreg/iTreg10
|
| tTreg (thymus-derived) |
In thymus |
CD4+Foxp3+… |
Variety |
| pTreg (peripherally derived) |
In periphery |
CD4+Foxp3+, from Foxp3− T-conventional cells |
Variety |
| iTreg (induced in cell culture) |
In cell culture |
CD4+Foxp3+… |
Variety |
|
TFR (follicular Treg)11
|
In germinal center |
CD4+Foxp3+Bcl-6+CXCR5+ICOS+CD19−, PD-1+GITR+
|
Direct contactIL-10/TGF-β |
|
cTreg/eTreg/tissue-resident Treg12
|
| cTreg (central Treg) |
Located in circulation and secondary lymphoid organs |
CD4+Foxp3+Blimp-1−CD62LhiCCR7+, CD45RAhiCD25lo
|
Variety |
| eTreg (effector Treg) |
Located in circulation, secondary lymphoid organs, various tissues |
CD4+Foxp3+Blimp-1+CD62LloCCR7lo, D44hiCD103+KLRG1+, CD45RAloCD25hi
|
Variety |
| Tissue-resident Treg1,2
|
Located in various tissues |
Phenotype of eTreg … |
Variety |
