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. 2015 Jul 13;12(5):580–591. doi: 10.1038/cmi.2015.57

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Copyright © 2015 Chinese Society of Immunology and The University of Science and Technology

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if thematerial is not included under the Creative Commons license, users will need to obtain permission fromthe license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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The SK-OV-3 cells induce a phenotypic differentiation of the CD8⁺ T cells in a transwell coculture system. (a) The expression of CD25, GITR, CTLA-4, Foxp3, and CD28 mRNA in the CD8⁺ T cells cultured with or without SK-OV-3 was analyzed by quantitative real-time PCR. (b) The CD8⁺ T cells in the transwell coculture system with SK-OV-3 expressed higher levels of the CTLA-4 and Foxp3 molecules and lower levels of CD28 than that in the CD8⁺ T cells cultured alone. The expression of CD25 and GITR was low, and there was no significant difference between the CD8⁺ T cells cultured with and without SK-OV-3. (c) Representative dot plots of the CD8 and Foxp3, CD28, and CTLA-4 staining of the CD8⁺ T cells cultured with or without SK-OV-3. *P < 0.05, **P < 0.01.