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. 2015 Aug 4;10(4):2027–2034. doi: 10.3892/ol.2015.3565

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Copyright: © Naruse et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Figure 1. — Representative immunohistochemical staining for VEGF-C, VEGFR-3 and podoplanin. (A) Negative staining for VEGF-C in OTSCC. (B) OTSCC with Bryne's score 2, displaying strong VEGF-C cytoplasmic expression (staining index, 12). Negative staining for VEGFR-3 (C) in the peritumoral stroma and (D) at the invasive front. Podoplanin expression (E) in the peritumoral stroma and (F) at the invasive front. VEGF-C, vascular endothelial growth factor-C; VEGFR-3, vascular endothelial growth factor receptor-3; OTSCC, oral tongue squamous cell carcinoma.