Fig. 5.

Intravitreous injection of HMGB1 allows induction of tEAU in Fas^lpr mice. Fas^lpr mice injected with IRBP_1–20-specific T cells were intravitreously injected with HMGB1 (1 μg/eye) or PBS (n = 9) on the day of cell transfer and examined on day 15; Wt mice (n = 9) injected with IRBP_1–20-specific T cells were used as the positive control. The pathological score for each group is presented as the mean ± SEM. *<p < 0.05 compared to Wt mice injected with IRBP_1–20-specific T cells and injected intravitreously with PBS using the Mann-Whitney U test