Table 2.
Association between clinical variables and objective response by RECIST
Variable | Total n | CR + PR n (%) | SD + PD n (%) | p value | |
---|---|---|---|---|---|
Grade | 1 + 2 | 74 | 42 (57) | 32 (43) | 0.01 |
3 | 9 | 1 (11) | 8 (89) | ||
Mucinous histology | no | 84 | 46 (55) | 38 (45) | 0.048 |
yes | 10 | 2 (20) | 8 (80) | ||
Liver metastasis | no | 31 | 8 (26) | 23 (74) | 0.001 |
yes | 64 | 40 (62) | 24 (38) | ||
Peritoneal metastasis | no | 79 | 43 (54) | 36 (46) | 0.09 |
yes | 16 | 5 (31) | 11 (69) | ||
Chemotherapy | FOLFIRI | 52 | 25 (48) | 27 (52) | 0.43 |
FOLFOX | 39 | 22 (56) | 17 (44) | ||
Hypertension | no | 61 | 29 (47) | 32 (53) | 0.41 |
yes | 30 | 17 (57) | 13 (43) | ||
Chemo + bevacizumab as first-line therapya | no | 28 | 9 (36) | 19 (64) | 0.02 |
yes | 67 | 40 (60) | 27 (40) |
RECIST: Response Evaluation Criteria in Solid Tumors; FOLFIRI: infusional 5-fluoro-uracyl plus leucovorin plus irinotecan; FOLFOX: infusional 5-fluoro-uracyl plus leucovorin plus oxaliplatin; CR: Complete Response; PR: Partial Response; SD: Stable Disease; PD: Progressive Disease (PD). Data are number of patients and numbers in parentheses are percentages. aChemo: chemotherapy