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. 2015 Aug 12;10(4):2063–2066. doi: 10.3892/ol.2015.3599

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Copyright: © Wang et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Figure 2. — Effects of gefitinib or/and GA therapy on PI3K and ERK pathways. The gefitinib-resistant NCI-H1975 xenografts were treated with gefitinib or/and GA on day 28 of the efficacy study. Tumor tissues were then collected 4 h later to detect levels of phosphorylated (p)-AKT (S473)/AKT, p-ERK (T202/Y204)/ERK (S240/244) and p-MEK/MEK. GA, gambogic acid.