Table 1.
Comparison of amounts and costs of hepatitis B immunoglobulin for combination prophylaxis with nucleos(t)ide analogues in previous publications[7,51]
| Ref. | Patients (n) | Protocol (HBIg) | Follow-up months median or average | HBV recurrence | HBIg amount V/1000IU/3 mo | HBIg cost US dollars |
| Markowitz et al[45] | 14 | 80KIU iv 1st month | 12 | 0 | 100 | 40000 |
| Then 10KIU iv/mo | ||||||
| Yao et al[[52] | 10 | 80KIU iv + 3.3KIU im x 1 mo | 15.6 | 1 (10) | 86.26 | 34500 |
| Then 1.48KIU im/mo | ||||||
| Yoshida et al[53] | 18 | 43.4KIU im 1st month | 18 | 0 | 52-67 | 20800-26800 |
| 4.3-6.8KIU im/mo thereafter | ||||||
| Mazano et al[47] | 33 | 46.5KIU iv 1st week | 30 | 1 (3) | 56.5 | 23000 |
| 5KIU/mo thereafter | ||||||
| Rosneau et al[46] | 21 | 45KIU iv 1st week | 21 | 2 (9.5) | > 45 | > 18000 |
| HBsAb > 500 until 14POD | ||||||
| HBsAb > 200 thereafter | ||||||
| Roche et al[31] | 15 | 80KIU iv 1st month | > 120 | 1 (6.6) | 100 | 40000 |
| 10KIU/month iv thereafter | ||||||
| Han et al[48] | 59 | 80KIU iv 1st month | 35 | 0 | 100 | 40000 |
| 10KIU/month iv thereafter | ||||||
| Seehofer et al[54] | 17 | 80KIU iv 1st month | 25 | 3 (18) | 83-84 | 25200-25600 |
| 1.5-2KIU/month to maintain | ||||||
| HBsAb > 100 | ||||||
| Wong et al[55] | 21 | 70KIU iv 1st month | 25 | 2 (9.5) | 90 | 36000 |
| 10KIU/month iv thereafter | ||||||
| Takaki et al[56] | 18 | 200IU/kg iv for 1 wk | 18 | 0 | 47 | 18800 |
| HBsAb > 100 following 5 mo | ||||||
| HBsAb > 10 thereafter | ||||||
| Buti et al[14] | 10KIU iv anhepatic phase | 18 | 1 (7.1) | 52 | 20800 | |
| 5KIU iv following 6 d | ||||||
| 4KIU im following 3 wk |
For these calculations, 1 US dollar = 100 yen. Estimated cost of HBIg: 400 dollars. HBV: Hepatitis B virus; HBIg: Hepatitis B immunoglobulin.