Table 3.
Genotype frequencies of TP53 polymorphism in cases and controls
| Patients/controls |
Genotype, % (n) |
OR1 | 95%CI | P value | ||
| Arg/Arg | Arg/Pro | Pro/Pro | ||||
| Cases (n = 642): | 56.9 (365) | 38.0 (244) | 5.1 (33) | 2.77 | 1.59-4.82 | 0.0001 |
| UC adult (n = 151) | 54.3 (82) | 38.4 (58) | 7.3 (11) | 2.50 | 1.34-4.65 | 0.0102 |
| CD adult (n = 138) | 55.8 (77) | 40.6 (56) | 3.6 (5) | 2.65 | 1.41-4.98 | 0.0011 |
| UC pediatric (n = 78) | 55.1 (43) | 41.0 (32) | 3.8 (3) | 2.58 | 1.29-5.17 | 0.0078 |
| CD pediatric (n = 94) | 59.6 (56) | 35.1 (33) | 5.3 (5) | 3.09 | 1.58-6.07 | 0.0023 |
| PSC (n = 42) | 64.3 (27) | 31.0 (13) | 4.8 (2) | 3.78 | 1.66-8.63 | 0.0046 |
| PSC + UC (n = 139) | 57.6 (80) | 37.4 (52) | 5.0 (7) | 2.85 | 1.52-5.35 | 0.0016 |
| Controls (n = 62) | 32.3 (20) | 53.2 (33) | 14.5 (9) | |||
1
OR is calculated for Arg/Arg vs Arg/Arg + Pro/Pro. CD: Crohn’s disease; UC: Ulcerative colitis; PSC: Primary sclerosing cholangitis.