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. 2015 Aug 14;10(4):2107–2117. doi: 10.3892/ol.2015.3609

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Copyright: © Li et al. This is an open access article distributed under the terms of a Creative Commons Attribution License.

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Figure 2. — Expression of FAS and HER2 in tumor and non-tumor (non-T) tissues. (A) Comparison of FAS expression between tumor and non-tumor tissues. The gastric cancer (GC) tissues overexpressed FAS (5.633±0.510 vs. 4.431±0.423; P=0.0001; Mann-Whitney rank test; or P<0.0001; χ² test). (B) Comparison of mHER2 staining status between tumor and non-tumor tissues. HER2 was significantly overexpressed in the GC tissues compared with the non-tumor tissues (P=0.0027; χ² test). (C) Comparison of cHER2 expression between tumor and non-tumor tissues. Unexpectedly, in contrast to mHER2, cHER2 was underexpressed in the GC tissues (4.441±0.481 vs. 5.662±0.465; P=0.0005; Mann-Whitney rank test; or P=0.0126; χ² test). FAS, fatty acid synthase; mHER2, membranous human epidermal growth factor receptor 2; cHER2, cytoplasmic HER2; US, ultimate score.