Table 1.
Live Offspring at Weaning (From Brm−/−;Brg1fl/+;cVECad‐Cre+×Brm−/−;Brg1fl/fl Matings)
| Genotype | No. of Observed* | No. of Expected |
|---|---|---|
| Brm −/− ;Brg1 fl/+ | 42 | 25 |
| Brm −/− ;Brg1 fl/fl | 30 | 25 |
| Brm −/− ;Brg1 fl/+ ;cVECad‐Cre + | 29 | 25 |
| Brm −/− ;Brg1 fl/fl ;cVECad‐Cre + | 0 | 25 |
Vascular Brg1/Brm double mutants do not survive until weaning. Thirteen litters of mice generated from crosses between Brm−/−;Brg1fl/+;cVECad‐Cre+ males and Brm−/−;Brg1fl/fl females were genotyped 18 to 20 days after birth. No Brg1/Brm double mutants were genotyped at this age [χ2(3dof): P<0.001]. Brg1 indicates Brahma‐related gene 1; Brm, Brahma.
*
P<0.001.