Table 2.
Brm −/− | Brg1 fl/fl ;cVECad‐Cre | Brg1 fl/fl ;Cdh5(PAC)‐Cre ERT2 | Brm −/− ;Brg1 fl/fl ;Cdh5(PAC)‐Cre ERT2 * * | |
---|---|---|---|---|
Retinas* | Small increase in vascular branching | Small decrease in vascular branching | No phenotype | No phenotype |
Exercised quadriceps* | No phenotype | No phenotype | No phenotype | Not assessed |
LLC tumors* | No phenotype | No phenotype | No phenotype | No phenotype |
Brg1 indicates Brahma‐related gene 1; Brm, Brahma; LLC, Lewis lung carcinoma.
Infants induced at postnatal day 3 (P3) to P5 die between P13 and P19 with gut and heart hemorrhage.
Adults induced at 6 weeks have low penetrance lethality (19%).
Induced at P3 to P5 for Cdh5(PAC)‐CreERT2 animals; analyzed at P7 for all genotypes.
Induced at 6 weeks for Cdh5(PAC)‐CreERT2 animals; analyzed at 11 weeks for all genotypes.