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. 2015 Apr 22;4(4):e001972. doi: 10.1161/JAHA.115.001972

Table 2.

Summary of Genotypes and Postnatal Angiogenesis Phenotypes

Brm −/− Brg1 fl/fl ;cVECad‐Cre Brg1 fl/fl ;Cdh5(PAC)‐Cre ERT2 Brm −/− ;Brg1 fl/fl ;Cdh5(PAC)‐Cre ERT2 * *
Retinas* Small increase in vascular branching Small decrease in vascular branching No phenotype No phenotype
Exercised quadriceps* No phenotype No phenotype No phenotype Not assessed
LLC tumors* No phenotype No phenotype No phenotype No phenotype

Brg1 indicates Brahma‐related gene 1; Brm, Brahma; LLC, Lewis lung carcinoma.

*

Infants induced at postnatal day 3 (P3) to P5 die between P13 and P19 with gut and heart hemorrhage.

*

Adults induced at 6 weeks have low penetrance lethality (19%).

*

Induced at P3 to P5 for Cdh5(PAC)‐CreERT2 animals; analyzed at P7 for all genotypes.

*

Induced at 6 weeks for Cdh5(PAC)‐CreERT2 animals; analyzed at 11 weeks for all genotypes.