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. 2015 Mar 27;4(4):e001868. doi: 10.1161/JAHA.115.001868

Figure 15.

Figure 15.

The MMP‐2 inhibitor doxycycline replicates aspects of the phenotype of Mmp2 deficiency. A, Analysis of WT mice administered doxycycline (50 mg/kg per day) for 0 to 15 days (2 weeks). (n=4 mice per time point). The sPLA2 activity of pools was measured in duplicate. *P≤0.05 vs day 0. One‐way repeated‐measures ANOVA. All pairwise multiple‐comparison procedures (Student‐Newman‐Keuls method). qRT‐PCR analysis of indicated inflammatory markers was conducted for individual mice. *P≤0.05 vs day 0. All pairwise multiple comparisons (Holm–Sidak method). B, Analysis of Mmp2−/− mice administered doxycycline (50 mg/kg per day) for 0 to 15 days (2 weeks). (n=3 per time point). The sPLA2 activity of pools was measured in duplicate. qRT‐PCR analysis of indicated inflammatory markers was conducted for individual mice. *P≤0.05 vs day 0. All pairwise multiple comparisons (Holm–Sidak method). ANOVA indicates analysis of variance; MMP, matrix metalloproteinase; qRT‐PCR, quantitative real‐time polymerase chain reaction; sPLA2, secreted phospholipase A2; WT, wild‐type.