Figure 16.

Emerging functions of the MMP‐2/sPLA₂ axis in cardiac inflammatory gene expression. A, Cardiac PGE₂ concentrations in mice treated with or without varespladib (10 mg/kg per day for 2 days). Pools of n=3 mice per genotype were measured in duplicate. B, qRT‐PCR of inflammatory marker genes in mice treated with or without varespladib (10 mg/kg per day for 2 days). n=3 mice per genotype. *P≤0.05 vs WT−Varespladib (control). ^†P≤0.05 vs Mmp2^−/−−Varespladib (control). All pairwise multiple comparisons vs control group (Holm–Sidak method). MMP indicates matrix metalloproteinase; PGE₂, prostaglandin E₂; qRT‐PCR, quantitative real‐time polymerase chain reaction; sPLA₂, secreted phospholipase A₂; WT, wild‐type.