Table I.
Significantly differentially expressed known miRNAs in osteosarcoma.
| miRNA ID | Log2, fold-changea | Adjusted P-value |
|---|---|---|
| Upregulated | ||
| hsa-miR-512-3p | 9.39 | 2.80×10−62 |
| hsa-miR-377-5p | 8.90 | 1.95×10−9 |
| hsa-miR-433-3p | 8.60 | 1.54×10−5 |
| hsa-miR-1323 | 8.45 | 4.72×10−5 |
| hsa-miR-337-3p | 8.11 | 5.30×10−22 |
| hsa-miR-485-3p | 8.07 | 8.00×10−56 |
| hsa-miR-6503-5p | 8.07 | 8.08×10−7 |
| hsa-miR-656-3p | 7.99 | <0 |
| hsa-miR-411-3p | 7.94 | 6.82×10−8 |
| hsa-miR-494-3p | 7.85 | 1.98×10−4 |
| hsa-miR-4709-5p | 7.81 | 7.79×10−4 |
| hsa-miR-508-3p | 7.76 | 1.23×10−6 |
| hsa-miR-187-3p | 7.54 | 6.42×10−12 |
| hsa-miR-370-5p | 7.54 | 4.12×10−9 |
| hsa-miR-105-3p | 7.42 | 1.08×10−105 |
| hsa-miR-873-3p | 7.37 | 3.22×10−4 |
| hsa-miR-1185-5p | 7.07 | 1.36×10−51 |
| hsa-miR-541-3p | 7.07 | 7.67×10−6 |
| hsa-miR-885-5p | 7.07 | 3.50×10−16 |
| hsa-miR-329-5p | 6.99 | 7.26×10−4 |
| hsa-miR-337-5p | 6.99 | 1.84×10−3 |
| hsa-miR-219a-1-3p | 6.90 | 2.34×10−13 |
| hsa-miR-329-3p | 6.90 | <0 |
| hsa-miR-134-3p | 6.81 | <0 |
| hsa-miR-134-5p | 6.80 | 1.83×10−22 |
| hsa-miR-654-5p | 6.77 | <0 |
| hsa-miR-758-3p | 6.77 | 1.44×10−5 |
| hsa-miR-487b-3p | 6.72 | 2.48×10−6 |
| hsa-miR-20b-3p | 6.71 | 3.18×10−292 |
| hsa-miR-380-3p | 6.71 | 3.27×10−5 |
| hsa-miR-654-3p | 6.42 | 4.30×10−31 |
| hsa-miR-432-5p | 6.35 | 1.67×10−16 |
| hsa-miR-105-5p | 6.25 | 3.64×10−22 |
| hsa-miR-409-3p | 6.21 | 2.26×10−3 |
| hsa-miR-1269b | 5.97 | 9.01×10−4 |
| hsa-miR-493-3p | 5.93 | 5.29×10−97 |
| hsa-miR-431-3p | 5.73 | <0 |
| hsa-miR-127-3p | 5.57 | 3.27×10−11 |
| hsa-miR-409-5p | 5.56 | 5.01×10−3 |
| hsa-miR-370-3p | 5.54 | 5.75×10−7 |
| hsa-miR-767-5p | 5.54 | 2.20×10−7 |
| hsa-miR-410-3p | 5.54 | 9.27×10−3 |
| hsa-miR-493-5p | 5.51 | <0 |
| hsa-miR-487a-3p | 5.50 | 1.24×10−8 |
| hsa-miR-520a-3p | 5.41 | 4.47×10−10 |
| hsa-miR-381-3p | 5.24 | 4.87×10−14 |
| hsa-miR-149-5p | 5.22 | 1.42×10−3 |
| Downregulated | ||
| hsa-miR-33a-5p | −7.46 | <0 |
| hsa-miR-551b-3p | −6.98 | 6.63×10−5 |
| hsa-miR-3613-5p | −5.17 | 1.53×10−3 |
| hsa-miR-144-3p | −4.47 | <0 |
| hsa-miR-190a-5p | −3.28 | 6.73×10−83 |
| hsa-miR-335-5p | −2.90 | 1.59×10−9 |
| hsa-miR-144-5p | −2.75 | 9.27×10−13 |
| hsa-miR-224-3p | −2.71 | 1.72×10−140 |
| hsa-miR-193a-3p | −2.46 | 1.63×10−55 |
| hsa-miR-19a-3p | −2.46 | 4.56×10−6 |
| hsa-miR-33b-5p | −2.26 | <0 |
| hsa-miR-452-3p | −2.17 | 9.84×10−289 |
| hsa-miR-29c-3p | −2.12 | 1.43×10−18 |
| hsa-miR-101-3p | −2.11 | <0 |
| hsa-miR-2467-5p | −2.10 | 5.55×10−10 |
| hsa-miR-378a-5p | −2.08 | 1.13×10−5 |
| hsa-miR-145-5p | −2.04 | 1.22×10−7 |
a
fold change = (osteosarcoma/normal bone tissue). miR/miRNA, microRNA; ID, identification; hsa, Homo sapiens.