Table I.

Clinical presentation of four patients treated with FOLFIRINOX^a.

			Dysarthria
Patient	Age and gender	Onset from start of irinotecan	Duration	Outcome	Recurrence	Atropine effective	Other symptoms
1	42, female	1 h	10 h	Reversible	Yes, but less intense	Yes	Distal extremity paresthesia
2	58, female	90 min	10 h	Reversible	Yes, but less intense	Yes	None
3	64, male	90 min	2 h (with atropine)	Reversible	No	Yes	Rhinitis, diaphoresis, abdominal pain, diarrhea
4	62, male	Immediate	2 h (with atropine)	Reversible	Yes, but less intense	Yes	Pharyngolaryngeal dysesthesia

^aOxaliplatin 85 mg/m² was administered intravenously over the course of 2 h, followed by irinotecan 180 mg/m² over the course of 90 min and l-leucovorin 200 mg/m² over the course of 2 h, followed immediately by fluorouracil 400 mg/m² as an intravenous bolus and then 2,400 mg/m² as a 46-h continuous infusion, usually with anti-emetic premedication with palonosetron and dexamethasone. Prophylactic atropine was not used in the first course.