Table III.
The correlation between the methylation state of GSTP1and P16genes with the clinicopathological data of HCC patients.
| GSTP1 methylation | P16 methylation | |||||
|---|---|---|---|---|---|---|
| Clinicopathology | - | + | P-value | - | + | P-value |
| Gender | 0.473 | 0.452 | ||||
| Male | 11 | 16 | 13 | 14 | ||
| Female | 4 | 4 | 3 | 5 | ||
| Age (years) | 0.281 | 0.364 | ||||
| ≤50 | 6 | 5 | 6 | 5 | ||
| >50 | 9 | 15 | 10 | 14 | ||
| AFP (µg/l) | 0.518 | 0.156 | ||||
| ≤20 | 6 | 7 | 4 | 9 | ||
| >20 | 9 | 13 | 12 | 10 | ||
| Tumor size (cm) | 0.404 | 0.210 | ||||
| ≤5 | 9 | 10 | 7 | 12 | ||
| >5 | 6 | 10 | 9 | 7 | ||
| Cirrhosis | 0.482 | 0.347 | ||||
| + | 10 | 12 | 9 | 13 | ||
| - | 5 | 8 | 7 | 6 | ||
| HbsAg | 0.668 | 0.024 | ||||
| + | 12 | 16 | 10 | 18 | ||
| - | 3 | 4 | 6 | 1 | ||
| Capsular invasion | 0.017 | 0.596 | ||||
| + | 5 | 15 | 9 | 11 | ||
| - | 10 | 5 | 7 | 8 | ||
| Distal metastasis | 0.567 | 0.481 | ||||
| + | 4 | 6 | 4 | 6 | ||
| - | 11 | 14 | 12 | 13 | ||
| Differentiation | 0.340 | 0.602 | ||||
| High to medium | 13 | 15 | 13 | 15 | ||
| Poor | 2 | 5 | 3 | 4 | ||
HCC, hepatocellular carcinoma; AFP, α-fetoprotein; HbsAg, hepatitis B surface antigen.