Table IV.
The correlation of the methylation state of RIZ1and RASSF1Agenes with the clinicopathological data of HCC patients.
| RIZ1 methylation | RASSF1A methylation | |||||
|---|---|---|---|---|---|---|
| Clinicopathology | - | + | P-value | - | + | P-value |
| Gender | 0.492 | 0.665 | ||||
| Male | 8 | 19 | 3 | 24 | ||
| Female | 3 | 5 | 1 | 7 | ||
| Age (years) | 0.521 | 0.372 | ||||
| ≤50 | 3 | 8 | 2 | 9 | ||
| >50 | 8 | 16 | 2 | 22 | ||
| AFP (µg/l) | 0.626 | 0.522 | ||||
| ≤20 | 4 | 9 | 1 | 12 | ||
| >20 | 7 | 15 | 3 | 19 | ||
| Tumor size (cm) | 0.352 | 0.630 | ||||
| ≤5 | 7 | 12 | 2 | 17 | ||
| >5 | 4 | 12 | 2 | 14 | ||
| Cirrhosis | 0.144 | 0.478 | ||||
| + | 5 | 17 | 2 | 20 | ||
| - | 6 | 7 | 2 | 11 | ||
| HbsAg | 0.619 | 0.609 | ||||
| + | 9 | 19 | 3 | 25 | ||
| - | 2 | 5 | 1 | 6 | ||
| Capsular invasion | 0.281 | 0.200 | ||||
| + | 5 | 15 | 1 | 19 | ||
| - | 6 | 9 | 3 | 12 | ||
| Distal metastasis | 0.309 | 0.681 | ||||
| + | 2 | 8 | 1 | 9 | ||
| - | 9 | 16 | 3 | 22 | ||
| Differentiation | 0.619 | 0.609 | ||||
| High to medium | 9 | 19 | 3 | 25 | ||
| Poor | 2 | 5 | 1 | 6 | ||
HCC, hepatocellular carcinoma; AFP, α-fetoprotein; HbsAg, hepatitis B surface antigen.