Figure 3.

EGFR signaling pathway was significantly suppressed with PTX treatment. (A) Histochemistry staining demonstrated that EGFR was significantly increased in human oral cancer tissues compared with the normal tissue. (B) Western blot analysis revealed that PTX inhibited EGF-induced EGFR activation. (C) Western blot analysis demonstrated reduced c-Jun N-terminal kinases, extracellular signal-regulated kinases, p38 activation of EGFR signaling pathways. Data represent the means ± standard error of the mean, n=3 independent experiments. *P<0.05 versus control. Epidermal growth factor receptor; PTX, paclitaxel.