Table II.
Univariate and multivariate analyses of prognostic factors for non-small cell lung cancer patients subsequent to treatment with platinum-based chemotherapy.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P-value | HR (95% CI) | P-value |
| CTR1 expression | ||||
| High vs. low | 0.15 (0.62–0.38) | 0.000 | 0.29 (0.11–0.75) | 0.010 |
| ATP7A expression | ||||
| High vs. low | 7.20 (2.48–20.87) | 0.000 | 3.68 (1.11–12.12) | 0.032 |
| ATP7B expression | ||||
| High vs. low | 1.78 (0.78–4.03) | 0.168 | 0.77 (0.29–2.00) | 0.592 |
| Gender | ||||
| Male vs. female | 0.29 (0.10–0.85) | 0.023 | 0.28 (0.09–0.95) | 0.040 |
| Age | ||||
| ≥60 vs. <60 years | 0.97 (0.93–1.00) | 0.083 | 0.96 (0.92–1.01) | 0.120 |
| Tumor differentiation | ||||
| Good/moderate vs. poor | 0.31 (0.19–0.49) | 0.000 | 0.44 (0.24–0.79) | 0.006 |
HR, hazard ratio; CI, confidence interval; CTR1, copper transporter 1; ATP7A, copper-transporting p-type adenosine triphosphatase 1; ATP7B, copper-transporting p-type adenosine triphosphatase 2.