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. 2015 Feb 3;3(4):e1009276. doi: 10.1080/21623996.2015.1009276

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Figure 5. — Loss of WAVE3 inhibits the STAT1-HIF-1α signaling cascade that is usually activated by chemotherapy in TNBCs. Western blot analysis with the indicated antibodies of cell lysates form the control shRNA (ctrl-sh)- or sh-WAVE3-expressing (W3-sh) MDA-MB-231 cells after doxorubicin (Dox) or docetaxel (Doc) treatment. β-actin served as a loading control. The numbers below the HIF-1α, p-STAT1 and WAVE3 panels indicate the fold change of HIF-1α, p-STAT1 and WAVE3 levels, respectively, as compared to the untreated Ctrl-sh cells.