Table 4.

Predictive value of the cuff leak test and laryngeal ultrasonography for postextubation stridor, laryngeal edema, and reintubation

Author	Year	Predefined cutoff value		Outcome	Sensitivity	Specificity	PPV	NPV
Cuff leak test		Volume, ml	Percentage of tidal volume
Miller and Cole [22]	1996	110		Stridor	0.67 (0.51–0.82)	0.99	0.80	0.98
Jaber et al. [25]	2003	130	12	Stridor	0.85 (0.65–0.99)	0.95 (0.91–0.99)	0.69	0.98
De Bast et al. [2]	2002		15.5	Reintubation	0.75	0.72	0.25	0.96
Sandhu et al. [21]	2000		10.0	Stridor or reintubation	0.54	0.96	0.64	0.94
Wang et al. [19]	2007	88		Stridor	0.60	0.89	0.55	0.91
Maury et al. [20]	2004	0		Stridor	1.00	0.80	0.15	1.00
Chung et al. [13]	2006	140		Laryngeal edema	0.89	0.90	0.84	0.93
Engoren [34]	1999	110		Stridor	0.00	0.96	0.00	0.99
Kriner et al. [18]	2005	110		Stridor	0.50	0.84	0.12	0.97
Cheng et al. [16]	2006		18.0	Stridor	0.85	0.72	0.21	0.98
Mikaeili et al. [28]	2014	110		Stridor	0.25	0.84	0.14	0.91
		130			0.25	0.81	0.13	0.91
		249			0.75	0.59	0.17	0.96
Gros et al. [27]	2012	130		Stridor	0.86 (0.42–1.00)	0.76 (0.67–0.84)	0.21 (0.08–0.40)	0.99 (0.93–1.00)
Sutherasan et al. [15]	2013	110		Laryngeal edema	0.80	0.82	0.46	0.96
Ultrasonography		ACWD, mm
Sutherasan et al. [15]	2013	1.6		Laryngeal edema	0.71	0.70	0.32	0.92
Mikaeili et al. [28]	2014	0.85		Stridor	0.50	0.57	0.11	0.91

95 % confidence intervals are provided if available

Adapted from Wittekamp et al. [4]

PPV positive predictive value, NPV negative predictive value, ACWD air column width difference