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. 2015 Sep 23;12:55. doi: 10.1186/s12950-015-0096-x

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© Vilekar et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — EF24 suppresses the LPS-induced IL-1R1 expression and IL-1β secretion in JAWS II DCs. (a) Quantitative-polymerase chain reaction for the measurement of the IL-1R1 mRNA expression (mean ± sem, fold changes as compared to control) in JAWS II DCs that were LPS (100 ng/ml)-stimulated for 4 h, followed by treatment with 10 μM EF24. # p value < 0.05 vs. control and * p value < 0.05 vs. LPS treatment. (b) Immunoblots of IL-1R1, IL-1R2, and IL-1RA expression in JAWS II DCs treated with EF24 and LPS. (c) IL-1β secreted in medium of cultured JAWS II DCs. The data is average (± sem) of samples from three separate experiments, each estimated in triplicate (# p value < 0.05 vs. control and * p value < 0.05 vs. LPS treatment)