TABLE 2.
Neutralizing antibody responses in DGY-infected pig-tailed macaques
| ΔGY group | Animal | Wk | ID50a |
||||
|---|---|---|---|---|---|---|---|
| ΔGY | SIVmac239 | SIVsmE660-2A5 | SIVsmE660-2A5.VTRN | SIVmac251.6 | |||
| Controllers | GC07 | Preinfection | <20 | <20 | <20 | <30 | <30 |
| 28 | <20 | <20 | <20 | 116,184 | 449,162 | ||
| 46 | 25 | <20 | 33 | 129,798 | 224,296 | ||
| GC72 | Preinfection | <20 | <20 | <20 | <30 | <30 | |
| 28 | <20 | <20 | <20 | 67,976 | 148,085 | ||
| 46 | <20 | <20 | <20 | 21,227 | 28,770 | ||
| GG10 | Preinfection | <20 | <20 | <20 | <30 | <30 | |
| 28 | <20 | <20 | <20 | 36,583 | 146,101 | ||
| 46 | <20 | <20 | <20 | 51,937 | 199,495 | ||
| GR29 | Preinfection | <20 | <20 | <20 | <30 | 32 | |
| 28 | 70 | 58 | <20 | 20,807 | 195,239 | ||
| 46 | 87 | 72 | <20 | 9,578 | 118,720 | ||
| HC67 | Preinfection | <20 | <20 | <20 | <30 | <30 | |
| 28 | <20 | <20 | <20 | >2,343,750 | 439,034 | ||
| 46 | <20 | <20 | 46 | >2,343,750 | 176,889 | ||
| HJ98 | Preinfection | <20 | <20 | <20 | <30 | <30 | |
| 28 | 21 | <20 | <20 | 44,620 | >2,343,750 | ||
| 46 | <20 | <20 | <20 | 579,940 | 324,247 | ||
| Progressors | GR26 | Preinfection | <20 | <20 | <20 | <30 | 103 |
| 28 | 30 | <20 | <20 | >2,343,750 | >2,343,750 | ||
| 46 | 56 | 21 | <20 | >2,343,750 | >2,343,750 | ||
| HA94 | Preinfection | <20 | <20 | <20 | <30 | <30 | |
| 28 | <20 | <20 | <20 | 44,620 | 408,428 | ||
| 46 | 67 | 21 | <20 | 579,940 | >2,343,750 | ||
a
ID50 values determined on TZM-bl cells for ΔGY-infected controlling and -progressing pig-tailed macaques using sera obtained before or at 28 or 46 weeks after infection. Neutralizing antibody responses of autologous sera to ΔGY and neutralization sensitivity of a panel of neutralization-sensitive and neutralization-resistant viruses are indicated. Neutralization-sensitive SIVsmE660-2A5.VTRN was generated by introducing 4 amino acid changes into neutralization-resistant SIVsmE660-2A5 (46).