TABLE 1.
Genes differentially induced by IFN-γ in Huh-7 and Huh6 cellsa
| Gene product | Fold difference between Huh-7 and Huh6 cells |
|---|---|
| CXCL92 | 13.8 |
| BTN3A31 | 10.5 |
| CASP11 | 9.4 |
| CARD161 | 8.5 |
| CXCL112 | 7.0 |
| MX13 | 6.8 |
| HLA-B4 | 6.1 |
| BTN3A21 | 5.6 |
| C1R2 | 5.5 |
| CFH2 | 5.5 |
| HERC61 | 4.3 |
| SERPINA71 | 4.0 |
| CTSS1 | 3.9 |
| IL-72 | 3.8 |
| HLA-A4 | 3.6 |
| TRIM311 | 3.5 |
| MT2A2 | 3.4 |
| NLRC51 | 3.2 |
| DDX60L1 | 3.2 |
| TLR33 | 3.1 |
| IL-322 | 3.1 |
| CFB2 | 3.1 |
| ACY31 | 3.0 |
a
IFN-γ-induced genes that are more strongly upregulated in Huh-7 compared to Huh6 identified by microarray gene expression analysis. Factors shown in bold were used for further analysis. Exclusion of factors in regular font was based on the following criteria, indicated by superscript numbers as follows: 1, candidate effector for further analysis; 2, secreted factor; 3, no anti-HCV activity; 4, unlikely direct effector.