FIG 4.

p10 is an integral part of the assembled lattice. Representations of p10-CA-NTD interactions are shown. Flexible fits alone and with the corresponding EM density are shown in the left and right panels, respectively. Arrowheads mark the proteolytic cleavage site between p10 and CA. (a) Three p10-CA-NTD monomers are shown from the outside of the VLP with one monomer highlighted in yellow (p10) and blue (CA-NTD). The hole on the 6-fold axis is indicated by black lines. (b and c) Side view of two p10-CA-NTD monomers as seen from the hexamer center (b) and rotated by 180° around the vertical axis (c). For clarity, one p10-CA-NTD monomer has been removed from the side views in panels b and c.