FIG 3.

Epitopes targeted in SP and their sequence variants. (A) PIC51861; (B) PIC64236; (C) PIC68008; (D) PIC44149; (E) PIC99203. Optimal epitopes were experimentally defined except where noted and are represented by shaded areas within 15-mer sequences. Red labels indicate epitope variants that reached >80% frequency in the viral population (i.e., the replacement variant), and yellow highlighting represents de novo epitopes containing escape mutations to founder-specific responses. Time points used for immunological assays are noted for each SP.