FIG 4.

Multiple variants often found within targeted epitopes. (A) Number of epitope variants detected in each of the 20 responses detected in the SPs. The absence of detection of epitope variants indicates a persistent epitope. (B) Epitope entropy is correlated to the number of epitope variants detected per response. (C) The nine epitopes in which a replacement variant was selected in the viral population are listed on the x axis. For each epitope, the duration (in dps) is shown between the time the response was first detected and the time in which the replacement variant achieved >80% frequency in the viral population.