TABLE 4.
Incubation periods and median seeding titers of TME and CWD strains in HPrP7752KO mice and SGH
| Prion strain | HPrP7752KO mice |
Syrian golden hamsters |
||
|---|---|---|---|---|
| Mean incubation period (days) ± SEM | SD50 per mg of braina | Mean incubation period (days) ± SEM | SD50 per mg of brainb | |
| HY TME | 58 ± 1.6 | 107.2, 107.2 | 63 ± 2.1 | 109.2, 108.9, 108.9 |
| DY TME | 146 ± 5.1 | 106.2, 106.9 | 161 ± 2.0 | 107.2, 107.2, 108.7 |
| CKY CWD | 160 ± 4.6 | 108.7, 108.7 | 479 ± 6.4 | 109.9, 1010.4, 108.7 |
| WST CWD | 189 ± 5.7 | 106.9, 106.7 | 323 ± 2.1 | 107.7, 108.4, 107.7 |
| Mock | >250 | <102, <102 | >600 | <102, <102, <102 |
a
Tenfold serial dilutions of brain were used in an RT-QUiC assay to calculate the median seeding dose (SD50).
b
A one-way analysis of variance and Tukey's multiple-comparison test indicated a difference (P < 0.05) between CKY CWD and WST CWD and between CKY CWD and DY TME. Statistical analysis in transgenic mice was not performed due to the limited n value.