FIG 2.

Virulent SFV inhibits STAT1 activation in infected cells. (A) Tyr701-phosphorylated STAT1 quantified in infected Vero(B) cells after stimulation with 1,000 U/ml human IFN-β. (B) rA774 showed significantly reduced potency for inhibiting STAT1 activation. Band intensities were quantified by using ImageJ. Data presented are means of three replicate analyses ± SD. (C) SFV4 and SFV4-miRT124 but not VA7-EGFP show P-STAT1 inhibition in CT-2A-Fluc cells. Results show phosphorylated STAT1 detected from CT-2A-Fluc cells that were either treated or not with 1,000 U/ml mouse IFN-β 6 h postinfection.