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. 2015 Oct;63(4):934–942. doi: 10.1016/j.jhep.2015.05.013

Fig. 4.

Fig. 4

Identification of colon-associated genes in HLC. The graphs on the left indicate the mRNA expression levels of the transcription factors KLF5 and CDX2, and the colon genes MEP1A and CDH17, in ESC and HLC. The tissue specificity for these genes was validated by querying the Proteinatlas® [30]. Here, representative pictures of immunostainings for the aforementioned genes are shown, indicating the nuclear expression of KLF5 and CDX2 in colon crypts, and the membranous expression of MEP1A and CDH17. The colon-enriched expression for these genes is also shown at the transcriptional level (RNAseq).