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. 2015 Sep 23;13:79. doi: 10.1186/s12915-015-0189-2

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© Nijhout et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Homeostasis of extracellular dopamine. Model simulations of the effect of progressive cell death on the concentration of extracellular dopamine. Black: dopamine concentration declines less than 10 % until more than 80 % of cells have died. White: effect of reducing the activity of the dopamine reuptake transporter (DAT); now the level of extracellular dopamine is very sensitive to the size of the cell population. After [4, 26]