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. 2015 Sep 20;23(9):734–746. doi: 10.1089/ars.2015.6247

FIG. 5.

FIG. 5.

Redox network structure supports adaptation to the environment. (A) Oxidation cycles for Prx are linked to clock protein expression. The oxidation cycle for peroxiredoxin-6 (Prx-SO2/3) is shown for fly (Drosophila melanogaster) with clock protein timeless (TIM), fungus (Neurospora crassa) with clock protein (FRQ), and mouse (Mus musculus) Prx1 with circadian protein BMAL. Similar variation in Cys/CySS is shown for human plasma. Figures were redrawn and simplified from original publications; originals should be consulted for statistical measurements and additional details and validations. (B) Progressive oxidation with age, shown by human plasma Cys/CySS and GSH/GSSG, contributes to decline in adaptability. (A) Composite modified from Edgar et al. (24) and Blanco et al. (9); (B), modified from Jones et al. (49). BMAL, transcriptional activator, core component of circadian clock; GSSG, glutathione disulfide; Prx1, peroxiredoxin-1.