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. Author manuscript; available in PMC: 2015 Sep 23.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2013 Jun 28;3(1):69–81. doi: 10.1002/wdev.122

Figure 2. Genetic mosaics by site-specific mitotic recombination.

Figure 2

(A) A heterozygous parental cell can give rise to two distinct daughter cells homozygous for different alleles of genes and transgenes residing distal to the site of mitotic recombination (orange triangles: FRTs; recombination between FRTs requires FLP). The resulting homozygous daughter cells and their offspring can be distinguished from the surrounding heterozygous cells based on the copy number of the marker transgene (green). One can further enrich clones homozygous for the recessive x mutation by incorporating a dominant slow-growing Y mutation onto the otherwise wild-type homologous chromosome arm.

(B) A schematic heterozygous wing disc (light green) carries a large x/x mutant clone (unmarked) paired with a tiny Y/Y sister clone (dark green). The mutant clone shows growth advantages due to the absence of the dominant slow-growth Y mutation.