Table 2.

A summary of the PICOS elements that comprise the systematic review

Population	Intervention	Comparison	Outcome	Study design
Primary care doctors working alone, in group practices and healthcare teams in any country	Any (psychosocial) intervention or combination of interventions developed to improve any element or combination of elements of well-being.	No intervention or usual support and care	Primary: all well-being outcomes related to any of the 20 aspects of well-being identified in Table 1 or combinations thereof including improvement in mental illness, measures of stress, anxiety, depression, addiction and burnout	Randomised controlled trials including cluster randomised trials
				Non-randomised controlled trials
				Controlled before-and-after trials
				Interrupted time series trials
			Secondary: physiological outcome measures of improvement in well-being, e.g. cortisol.