Table 4. Cox regression analyses for predictors of outcome (BCSS and DM).

	BCSS				DM
			95% CI				95% CI
Parameters	P-value	HR	Lower	Upper	P-value	HR	Lower	Upper
Tumour stage	<0.0001	1.92	1.7	2.2	<0.0001	1.8	1.6	1.9
Tumour grade	<0.001	1.87	1.5	2.3	0.034	1.2	1.01	1.3
Tumour size	0.001	1.07	1.03	111	0.206	1.03	0.98	1.09
KPNA2	0.221	1.15	0.87	1.4	0.227	1.2	0.92	1.4
Adjuvant therapy subgroup
Tumour stage	<0.0001	2.05	1.7	2.5	<0.0001	1.8	1.6	1.9
Tumour grade	<0.001	2.30	1.6	3.3	0.034	1.2	1.01	1.3
Tumour size	0.087	1.18	0.98	1.3	0.206	1.03	0.98	1.09
KPNA2	0.300	1.13	0.87	1.6	0.227	1.2	0.92	1.4
No adjuvant therapy subgroup
Tumour stage	0.006	1.64	1.1	2.3	0.001	1.6	1.2	2.1
Tumour grade	<0.001	1.75	1.3	2.4	0.206	1.1	0.9	1.4
Tumour size	<0.001	1.58	1.2	2.0	0.004	1.3	1.1	1.6
KPNA2	0.826	1.05	0.7	1.7	0.168	1.3	0.9	1.8

Abbreviations: BCSS=breast cancer-specific survival; CI=confidence interval; DM=distant metastasis; HR=hazard ratio; KPNA2=karyopherin α-2.