Table 3. The most cost-effective strategy, its next best alternative, and the Papanicolaou smear with the ICERs in a two-way sensitivity analysis with respect to screening frequency and ploidy cost factor.

	Ploidy cost factor=0.5		Ploidy cost factor=0.75		Ploidy cost factor=1.0
Screening frequency	Screening strategy	Strategy, ICER	Screening strategy	Strategy, ICER	Screening strategy	Strategy, ICER
Screening every 1 year	Most cost-effective	Ploidy 4 cell, $42 655	Most cost-effective	Ploidy 4 cell, $54 008	Most cost-effective	Ploidy 4 cell, $65 361
	Next best alternativea	Ploidy 3 cell, more than 1Mb	Next best alternative	Ploidy 3 cell, more than 1M	Next best alternative	Ploidy 3 cell, more than 1M
	Papanicolaou smear	Dominated	Papanicolaou smear	Dominated	Papanicolaou smear	Dominated
Screening every 2 years	Most cost-effective	Ploidy 4 cell, $24 161	Most cost-effective	Ploidy 4 cell, $30 699	Most cost-effective	Ploidy 4 cell, $37 238
	Next best alternative	Ploidy 3 cell, $284 249	Next best alternative	Ploidy 3 cell, $297 995	Next best alternative	Papanicolaou smear, $276 891
	Papanicolaou smear	$463 506	Papanicolaou smear	$351 416	Papanicolaou smear	$276 891
Screening every 3 years	Most cost-effective	Ploidy 4 cell, $18 824	Most cost-effective	Ploidy 4 cell, $23 270	Most cost-effective	Ploidy 4 cell, $28 277
	Next best alternative	Ploidy 3 cell, $132 803	Next best alternative	Ploidy 3 cell, $139 252	Next best alternative	Papanicolaou smear, $119 198
	Papanicolaou smear	$192 502	Papanicolaou smear	$148 501	Papanicolaou smear	$119 198
Screening every 5 years	Most cost-effective	Ploidy 4 cell, $13 157	Most cost-effective	Ploidy 4 cell, $16 916	Most cost-effective	Ploidy 4 cell, $20 674
	Next best alternative	Ploidy 3 cell, $66 184	Next best alternative	Ploidy 3 cell, $69 444	Next best alternative	Papanicolaou smear, $57 543
	Papanicolaou smear	$92 403	Papanicolaou smear	$71 278	Papanicolaou smear	$57 543
Screening every 10 years	Most cost-effective	Papanicolaou smear, $47 176	Most cost-effective	Papanicolaou smear, $36 727	Most cost-effective	Papanicolaou smear, $29 655
	Next best alternative	n/a	Next best alternative	n/a	Next best alternative	n/a
	Papanicolaou smear	$47 176	Papanicolaou smear	$36 727	Papanicolaou smear	$29 655

^aCompared to the most cost-effective strategy.

^bMore than $1 000 000/QALY.