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. 2015 May 19;112(12):1874–1881. doi: 10.1038/bjc.2015.144

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Copyright © 2015 Cancer Research UK

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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(A) Plasma concentration–time profiles of pimasertib 45 mg per day in the presence (day 1, open diamonds) and absence (day 8, closed diamonds) of FOLFIRI. Data (mean±s.d.) are shown as semilog (main figure) and linear (inset) plots. (B) Plasma concentration–time profiles of irinotecan in the presence (day 1, open diamonds) and absence (day 15, closed diamonds) of pimasertib 45 mg per day. Data (mean±s.d.) are shown as semilog (main figure) and linear (inset) plots. (C) Plasma concentration–time profiles of SN-38 in the presence (day 1, open diamonds) and absence (day 15, closed diamonds) of pimasertib 45 mg per day. Data (mean±s.d.) are shown as semilog (main figure) and linear (inset) plots.