Table 2. All-cause and cause-specifica standardised mortality ratios and absolute excess risk for bone sarcoma survivors within the British Childhood Cancer Survivor Study (BCCSS) overall and by tumour type.
|
All bone sarcoma survivors |
Osteosarcoma survivors |
Ewing sarcoma survivors |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Overall |
<25 Years follow-upb |
⩾25 Years follow-upb |
Overall |
Overall |
|||||||||||||||
| Underlying cause of death | Person-years | O/E | SMR (95% CI) | AER (95% CI)c | O/E | SMR (95% CI) | AER (95% CI)c | O/E | SMR (95% CI) | AER (95% CI)c | Person-years | O/E | SMR (95% CI) | AER (95% CI)c | Person-years | O/E | SMR (95% CI) | AER (95% CI)c | P-valued |
| All-causes | 15 678 | 131/18.7 | 7.0 (5.9, 8.3) | 71.6 (57.3, 86.0) | 115/9.1 | 12.7 (10.5, 15.2) | 82.7 (66.3, 99.1) | 16/9.6 | 1.7 (1.0,2.7) | 22.3 (−5.0,49.7) | 7539 | 53/8.9 | 6.0 (4.5, 7.8) | 58.5 (39.6, 77.5) | 5327 | 57/4.6 | 12.3 (9.4, 16.0) | 98.3 (70.6, 126.1) | <0.001 |
| Recurrence | 15 678 | 80/0.0 | NA | 51.0 (39.8, 62.2) | 79/0.0 | NA | 61.6 (48.1,75.2) | 1/0.0 | NA | 3.5 (−3.4, 10.3) | 7539 | 26/0.0 | NA | 34.5 (21.2, 47.7) | 5327 | 42/0.0 | NA | 78.8 (55.0, 102.7) | |
| SPN | 15 678 | 31/5.5 | 5.6 (3.8, 8.0) | 16.2 (9.3, 23.2) | 24/1.7 | 14.4 (9.2, 21.5) | 17.4 (9.9, 24.9) | 7/3.9 | 1.8 (0.7, 3.7) | 10.9 (−7.2, 29.0) | 7539 | 18/2.7 | 6.7 (4.0, 10.6) | 20.3 (9.3, 31.3) | 5327 | 8/1.1 | 7.1 (3.1, 14.1) | 12.9 (2.5, 23.3) | 0.772 |
| Circulatory | 15 678 | 8/3.6 | 2.3 (1.0, 4.4) | 2.8 (−0.7, 6.4) | 3/1.0 | 3.0 (0.6, 8.7) | 1.6 (−1.1, 4.2) | 5/2.5 | 2.0 (0.6, 4.6) | 8.6 (−6.7, 23.9) | 7539 | 3/1.7 | 1.8 (0.4, 5.3) | 1.8 (−2.7, 6.3) | 5327 | 2/0.7 | 3.0 (0.4, 11.0) | 2.5 (−2.7, 7.7) | 0.598 |
| External | 15 678 | 5/4.7 | 1.1 (0.3, 2.5) | 0.2 (−2.6, 3.0) | 5/3.9 | 1.3 (0.4, 3.0) | 0.8 (−2.6, 4.3) | 0/− | NP | NP | 7539 | 3/2.2 | 1.4 (0.3, 4.0) | 1.0 (−3.5, 5.5) | 5327 | 1/1.6 | 0.6 (0.0, 3.6) | −1.0 (−4.7, 2.6) | 0.535 |
Abbreviations: AER=absolute excess risk; CI=confidence intervals; E=expected number; NA=not applicable; NP=not possible to reliably calculate due to very small expected number; O=observed number; SMR=standardised mortality ratios.
a
Results are only reported for underlying causes of deaths with at least five observed events overall. Other causes of death were: four genitourinary, one digestive, one infection, and one unknown.
b
From five-year survival.
c
Per 10 000 person-years.
d
Comparing SMRs for osteosarcoma and Ewing sarcoma survivors.
SMRs and AERs where there are <5 observed events should be interpreted with caution.