. Author manuscript; available in PMC: 2015 Sep 23.

Published in final edited form as: J Diabetes Metab. 2015 Jun 1;6(6):1–7. doi: 10.4172/2155-6156.1000556

Table 2.

Effect of 6-week treatment with α-lipoic acid (LA) on basal metabolic parameters in 12 weeks old Obese Zucker diabetic fatty (ZDF) rats and age-matched Zucker lean (ZL) rats.

	ZL			ZL + LA			ZDF			ZDF + LA
Final body weight (g)	312	±	6	305	±	6	365	±	9 ^**	326	±	5 ⁺⁺
Plasma glucose (mmol/L)	5.8	±	0.4	5.3	±	0.3	16.8	±	1.8^**	12.9	±	1.7^**
Plasma insulin (pmol/L)	471.5	±	36.5	520.6	±	130.2	2098.9	±	313.5^**	2087.0	±	253.9^**
HOMA index	18.0	±	1.9	17.5	±	4.3	271.9	±	30.9^**	182.4	±	50.9^**

Data are means ± SEM obtained from 8 rats in each group.

^**

P < 0.01 vs ZL rats,

⁺⁺

P < 0.01 vs ZDF rats.

Intra-assay coefficient of variance for glucose and insulin in each group are: ZL (19.51, 21.90), ZL + LA (16.01, 70.74), ZDF (30.30, 42.52) and ZDF + LA (37.27, 34.29), respectively.