Table 2. Associations between polymorphisms in the APOA4-APOA5-ZNF259-BUD13 gene cluster and TG levels in 5347 Chinese Han participants.
SNP | Position a | Near gene | Genotype (major/minor) | MAF b | Effect size (s.e.m.) c | P d |
---|---|---|---|---|---|---|
rs17119975 | 116139767 | BUD13 | T/C | 0.232 | -0.089 (0.017) | 1.79×10−9 |
rs964184 | 116154127 | ZNF259 | C/G | 0.226 | 0.117 (0.024) | 9.28×10−18 |
rs4417316 | 116157511 | ZNF259 | C/T | 0.280 | -0.107 (0.022) | 3.34×10−13 |
rs6589566 | 116157633 | ZNF259 | A/G | 0.226 | 0.125 (0.019) | 1.96×10−18 |
rs651821 | 116167789 | APOA5 | T/C | 0.262 | 0.170 (0.014) | 2.35×10−32 |
rs7396835 | 116189238 | APOA4 | C/T | 0.339 | 0.100 (0.020) | 3.86×10−12 |
aChromosomal positions are based on the NCBI Build 36 of the genome.
bMAF, minor allele frequency.
cThe minor allele is the effect allele, and the major allele is the reference allele.
dThe P values for the effects of genotypes on plasma TG levels were assessed by multiple linear regression models with adjustment for age, sex and BMI.