Table 3. Associations of the haplotypes derived from the five polymorphisms in 5347 Chinese participants.
| Polymorphisms a | Haplotype frequencies b | |||||||
|---|---|---|---|---|---|---|---|---|
| rs17119975 (BUD13) | rs4417316 (ZNF259) | rs6589566 (ZNF259) | rs651821 (APOA5) | rs7396835 (APOA4) | Low TG group (<1.70 mmol/L) N = 3066(%) | High TG group (≥1.70 mmol/L) N = 1199(%) | P | OR(95% CI) |
| C | T | A | T | C | 632(20.62) | 190(15.83) | - | 1.00(Reference) |
| T | C | A | T | C | 1068(34.84) | 387(31.58) | 0.07 | 1.21(0.99–1.47) |
| T | C | G | C | T | 389(12.68) | 218(18.17) | 1.87×10−7 | 1.86(1.48–2.35) |
| T | C | A | T | T | 313(10.2) | 117(9.74) | 0.11 | 1.24(0.95–1.62) |
| T | C | G | C | C | 212(6.91) | 97(8.09) | 4.00×10−3 | 1.52(1.11–2.03) |
| T | C | A | C | C | 102(3.33) | 68(5.71) | 4.91×10−6 | 2.22(1.57–3.14) |
| C | T | A | T | T | 157(5.12) | 55(4.62) | 0.39 | 1.17(0.82–1.65) |
aThe reference haplotype CTATC included fewer TG related alleles in each SNP.
bThe criteria proposed for the clinical diagnosis of elevated TG levels by the NCEP ATP III arbitrarily: the clinical threshold of 1.7 mmol/L for TG levels was used to divide the subjects into ‘low’ or ‘high’ TG groups in our study.
Chi-square tests were used to compare the frequency of haplotypes between the low TG group and the high TG group.