Table 1.
Relative Risk of comorbidities in Myotonic Dystrophy
| Co-morbidity | Number Observed |
Number Expected |
P-value | Relative Risk | Mean Age at Diagnosis of Comorbidity1 (years) (SD; range) |
|---|---|---|---|---|---|
| Cardiac Conduction Disorder | 8 | 0.13 | 2.154E-12 | 60.2 (29.9, 108.6) | 39.6 (11.3; 18–48 years) |
| Obstructive Sleep Apnea | 12 | 1.23 | 8.042E-9 | 9.8 (5.6, 15.8) | 45.4 (13.4; 22–74) |
| Central Sleep Apnea | * | * | 4.486E-4 | 66.1 (11.7, 208.1) | * |
| Intellectual Disabilities | * | * | 0.0212 | 9.0 (1.6, 28.4) | * |
| Hypothyroidism | 6 | 2.32 | 0.0309 | 2.6 (1.1, 5.1) | 51.5 (21.8; 27–79) |
| Myotonic Cataract | * | * | 8.927E-4 | 1119.7 (57.6, 5311.4) | * |
| Any Cataract | 19 | 3.05 | 7.203E-10 | 6.23 (4.08, 9.15) | 41.3 (12.4; 20–59) |
*
-- indicates that the exact number is below 5 and cannot be reported due to data confidentiality
1
Mean age at diagnosis refers to the age at which the ICD-9 code for the comorbidity is used in the medical record for those individuals with myotonic dystrophy.
Abbreviations: Myotonic Dystrophy (DM), Myotonic Dystrophy type-1 (DM1), Myotonic Dystrophy type-2 (DM2), Utah Population Database (UPDB), University of Utah Health Sciences Center (UUHSC)