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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Pharm Res. 2015 May 5;32(10):3269–3281. doi: 10.1007/s11095-015-1703-5

Figure 1.

Figure 1

The mAb minimal PBPK model with allometric scaling of systemic clearance (CLp). Symbols and physiological restrictions are defined with Eq (1-4). The left box represents the venous plasma as in full PBPK models, but is not applied in the present model.