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Physiological parameters used for scaling of lymph flow and PK properties of 12 mAbs across species.
| Man | Sheep | Dog | Monkey | Cat | Rabbit | Rat | Mouse | |
|---|---|---|---|---|---|---|---|---|
| Body weight, kg | 70 | 40.8 | 28 | 3.5 | 3.0 | 2.5 | 0.3 | 0.020 |
| Thoracic duct a, ml/h/kg | 1.38 | 1.82 | 1.88 | NA | 2.56 | 1.68 | 4.10 | 4.80 |
| Lymph flow, ml/h/kg | 1.73 | 2.27 | 2.35 | 3.51 | 3.20 | 2.10 | 5.13 | 6.00 |
| ISF, L | 15.6 | NA | NA | 0.735 | NA | NA | 0.0699 | 0.00435 |
| Lymph volume (Vlymph ), L |
5.2 | NA | NA | 0.314 | NA | NA | 0.0162 | 0.0016 |
| Plasma (Vp), L | 2.6 | NA | NA | 0.157 | NA | NA | 0.0081 | 0.00085 |
