Table 2.
| a: Performance Characteristics of CDAI Cut points versus Patient Self-reported Improvement and Pain in CATCH (n=578 unique patients, 1169 visit pairs) | ||||||
|---|---|---|---|---|---|---|
| Variables Associated with Improvement |
CDAI Cutpoint for Improvement (Starting Disease Activity) |
N* | Sensitivity ** (95% CI) |
Specificity ** (95% CI) |
Positive Predictive Value** (95% CI) |
Negative Predictive Value** (95% CI) |
| Patient self-reported improvement (better vs. same/worse) | 1 (low) | 377 | 65 (60,70) | 70 (65,74) | 74 (70,79) | 60 (55,65) |
| 6 (moderate) | 436 | 59 (54,64) | 77 (73,81) | 80 (76,84) | 54 (49,59) | |
| 12 (high) | 356 | 84 (80,88) | 60 (55,65) | 81 (77,85) | 64 (59,69) | |
| Pain (>1 vs. ≤1) | 1 (low) | 349 | 84 (80,88) | 59 (54,64) | 36 (31,41) | 93 (90,96) |
| 6 (moderate) | 410 | 65 (61,70) | 68 (63,72) | 56 (51,61) | 76 (72,80) | |
| 12 (high) | 326 | 86 (82,90) | 57 (52,62) | 74 (69,79) | 74 (69,79) | |
| Pain (>2 vs. ≤ 2) | 1 (low) | 349 | 84 (80,88) | 54 (49,59) | 18 (14,22) | 97 (95,98) |
| 6 (moderate) | 410 | 69 (64,73) | 64 (59,69) | 38 (33,43) | 86 (82,89) | |
| 12 (high) | 326 | 88 (84,91) | 53 (47,58) | 66 (61,71) | 81 (76,85) | |
| HAQ (>0.31 vs. ≤ 0.31) | 1 (low) | 351 | 62 (57,67) | 52 (47,57) | 16 (12,20) | 90 (87,93) |
| 6 (moderate) | 410 | 65 (60,69) | 63 (59,68) | 43 (38,48) | 80 (77,84) | |
| 12 (high) | 325 | 81 (77,86) | 51 (45,56) | 69 (64,74) | 67 (62,72) | |
| b: Performance Characteristics of CDAI Cut points versus Patient Self-reported Worsening and Pain in CATCH for patients with low disease activity (n=381 unique patients, 627 visit pairs) | ||||||
|---|---|---|---|---|---|---|
| Worsening in | CDAI Cutpoint for Worsening |
N* | Sensitivity ** (95% CI) |
Specificity ** (95% CI) |
Positive Predictive Value** (95% CI) |
Negative Predictive Value** (95% CI) |
| Patient self-reported worsening (worse vs. same/better) | 2 | 627 | 58 (77,84) | 82 (80,85) | 38 (34,41) | 92 (89,94) |
| Pain (>1 vs. ≤ 1) | 2 | 581 | 66 (62,70) | 84 (81,87) | 45 (41,49) | 93 (90,95) |
| Pain (>2 vs. ≤ 2) | 2 | 581 | 71 (67,75) | 81 (78,84) | 31 (27,35) | 96 (94,98) |
| HAQ (> 0.31 vs. ≤ 0.31) | 2 | 582 | 66 (62,69) | 80 (77,84) | 28 (25,32) | 95 (93,97) |
*
n’s slightly vary across rows due to missing data for each outcome measure; rows for pain and HAQ are subsets of the first row for patient self-reported improvement;
**
results shown as % (95% Confidence Interval)
*
n’s slightly vary across rows due to missing data for each outcome measure; rows for pain and HAQ are subsets of the first row for patient self-reported improvement;
**
results shown as % (95% Confidence Interval)