Appendix 2.
| a: Performance Characteristics of CDAI Cut points versus Patient Self-reported Improvement and Pain in CATCH including fibromyalgia patients (n=611 unique patients contributing 1231 pairs) | ||||||
|---|---|---|---|---|---|---|
| Variables Improved | CDAI Cutpoint for Improvement (Starting Disease Activity) |
N* | Sensitivity (95% CI)** |
Specificity (95% CI)** |
Positive Predictive Value (95% CI)** |
Negative Predictive Value (95% CI)** |
| Patient self-reported improvement (better vs. same/worse) | 1 (low) | 390 | 65 (60,69) | 70 (65,74) | 74 (69,78) | 60 (55,65) |
| 6 (moderate) | 467 | 57 (53,62) | 78 (74,81) | 80 (76,83) | 54 (49,58) | |
| 12 (high) | 374 | 84 (80,88) | 58 (53,63) | 80 (76,84) | 65 (60,69) | |
| Pain (>1 vs. ≤ 1) | 1 (low) | 362 | 84 (80,87) | 60 (55,65) | 37 (32,42) | 93 (90,96) |
| 6 (moderate) | 439 | 63 (59,68) | 69 (65,73) | 55 (51,60) | 76 (71,80) | |
| 12 (high) | 343 | 86 (82,89) | 55 (50,60) | 72 (67,77) | 74 (69,79) | |
| Pain (>2 vs. ≤ 2) | 1 (low) | 362 | 83 (79,86) | 55 (50,60) | 18 (14,22) | 96 (94,98) |
| 6 (moderate) | 439 | 67 (63,72) | 64 (60,69) | 38 (33,42) | 86 (83,89) | |
| 12 (high) | 343 | 88 (84,91) | 51 (45,56) | 64 (59,69) | 81 (76,85) | |
| HAQ (> 0.31 vs. ≤ 0.31) | 1 (low) | 364 | 61 (56,66) | 53 (48,58) | 17 (13,21) | 90 (87,93) |
| 6 (moderate) | 439 | 61 (56,65) | 64 (60,69) | 42 (38,47) | 79 (75,83) | |
| 12 (high) | 342 | 81 (77,85) | 49 (43,54) | 67 (62,72) | 66 (61,71) | |
| b: Performance Characteristics of CDAI Cut points versus Patient Self-reported Improvement and Pain in CATCH, including fibromyalgia patients (n=392 unique patients contributing 641 pairs) | ||||||
|---|---|---|---|---|---|---|
| Worsening in | CDAI Cutpoint for Worsening |
N* | Sensitivity( 95% CI)** |
Specificity (95% CI)** |
Positive Predictive Value (95% CI)** |
Negative Predictive Value (95% CI)** |
| Patient self-reported worsening (worse vs. same/better) | 2 | 641 | 57 (54,61) | 82 (79,85) | 38 (34,41) | 91 (89,93) |
| Pain (>1 vs. ≤1) | 2 | 595 | 66 (63,70) | 84 (81,87) | 46 (42,50) | 92 (90,95) |
| Pain (>2 vs. ≤2) | 2 | 595 | 71 (67,74) | 81 (78,84) | 32 (28,35) | 96 (94,97) |
| HAQ (> 0.31 vs. ≤0.31) | 2 | 596 | 66 (62,69) | 80 (77,83) | 29 (25,32) | 95 (93,97) |
*
n’s slightly vary across rows due to missing data for each outcome measure; rows for pain and HAQ are subsets of the first row for patient self-reported improvement;
**
results shown as % (95% Confidence Interval)
*
n’s slightly vary across rows due to missing data for each outcome measure; rows for pain and HAQ are subsets of the first row for patient self-reported improvement;
**
results shown as % (95% Confidence Interval)