Table 1. Results of single marker and gene-based association analyses in the GWA study.
| SNP | CHR | Position | Allele | ASD | Control | Index SNP | LD range (kb) | OR | (95% confidence interval) | P-value | Nearby Genes a | P-value of Gene based analysis |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs12080993 | 1 | 54,178,501 | A | 0.378 | 0.291 | - | 1.48 | (1.23–1.78) | 3.57X10-05 | GLIS1 | 9.38X10-04 | |
| rs11204613 | 1 | 248,379,155 | G | 0.119 | 0.189 | rs10888329 | 31 | 0.58 | (0.45–0.75) | 4.06X10-05 | OR2M3 | 3.90X10-05 |
| rs10888329 | 1 | 248,404,654 | T | 0.119 | 0.196 | rs10888329 | 31 | 0.55 | (0.43–0.72) | 8.05X10-06 | OR2M4 | 3.40X10-05 |
| rs6672981 | 1 | 248,407,200 | C | 0.116 | 0.192 | rs10888329 | 31 | 0.55 | (0.42–0.72) | 9.64X10-06 | OR2M4 | 3.40X10-05 |
| rs4642918 | 1 | 248,411,057 | C | 0.116 | 0.191 | rs10888329 | 31 | 0.56 | (0.43–0.73) | 1.24X10-05 | OR2M4 | 3.40X10-05 |
| rs4397683 | 1 | 248,411,089 | C | 0.116 | 0.192 | rs10888329 | 31 | 0.55 | (0.42–0.72) | 9.86X10-06 | OR2M4 | 3.40X10-05 |
| rs3916984 | 2 | 157,445,840 | T | 0.176 | 0.258 | - | 0.62 | (0.49–0.77) | 2.25X10-05 | GPD2 | 5.79X10-04 | |
| rs13014164 | 2 | 170,271,231 | C | 0.087 | 0.045 | - | 2.04 | (1.45–2.87) | 3.23X10-05 | LRP2/BBS5 | 4.93X10-01 | |
| rs3914502 | 3 | 174,564,602 | T | 0.124 | 0.195 | rs3914502 | 16 | 0.58 | (0.45–0.76) | 4.09X10-05 | NAALADL2 | 3.43X10-02 |
| rs2222447 | 3 | 174,580,826 | A | 0.140 | 0.213 | rs3914502 | 16 | 0.60 | (0.47–0.77) | 4.81X10-05 | NAALADL2 | 3.43X10-02 |
| rs7697680 | 4 | 55,245,541 | G | 0.115 | 0.065 | - | 1.87 | (1.38–2.52) | 3.41X10-05 | PDGFRA | 5.15X10-01 | |
| rs11741756 | 5 | 132,579,659 | T | 0.175 | 0.113 | - | 1.67 | (1.31–2.13) | 3.64X10-05 | FSTL4 | 9.45X10-03 | |
| rs13211684 | 6 | 51,175,486 | G | 0.283 | 0.201 | - | 1.56 | (1.28–1.91) | 1.36X10-05 | |||
| rs12543592 | 8 | 123,511,652 | G | 0.398 | 0.496 | - | 0.67 | (0.56–0.81) | 1.63X10-05 | |||
| rs10966205 | 9 | 24,095,607 | A | 0.419 | 0.322 | - | 1.52 | (1.27–1.83) | 6.25X10-06 | |||
| rs7026342 | 9 | 111,280,201 | G | 0.111 | 0.063 | rs7026342 | ~1 | 1.86 | (1.38–2.52) | 4.13X10-05 | ||
| rs7030851 | 9 | 111,281,164 | A | 0.111 | 0.063 | rs7026342 | ~1 | 1.87 | (1.38–2.52) | 4.01X10-05 | ||
| rs10763893 | 10 | 33,011,229 | A | 0.084 | 0.043 | - | 2.06 | (1.46–2.93) | 3.26X10-05 | C10orf68 | 3.29X10-02 | |
| rs12366025 | 11 | 29,148,890 | T | 0.184 | 0.119 | rs7933990 | 65 | 1.67 | (1.31–2.11) | 2.49X10-05 | ||
| rs11030597 | 11 | 29,190,528 | C | 0.184 | 0.120 | rs7933990 | 65 | 1.65 | (1.30–2.10) | 3.35X10-05 | ||
| rs7933990 | 11 | 29,208,679 | A | 0.181 | 0.114 | rs7933990 | 65 | 1.72 | (1.35–2.19) | 9.40X10-06 | ||
| rs11030606 | 11 | 29,214,412 | T | 0.181 | 0.118 | rs7933990 | 65 | 1.65 | (1.30–2.10) | 3.65X10-05 | ||
| rs7953930 | 12 | 10,818,182 | G | 0.183 | 0.119 | rs16922945 | ~1 | 1.65 | (1.30–2.09) | 3.83X10-05 | STYK1 | 9.18X10-02 |
| rs16922945 | 12 | 10,819,146 | C | 0.148 | 0.085 | rs16922945 | ~1 | 1.86 | (1.43–2.43) | 3.43X10-06 | STYK1 | 9.18X10-02 |
| rs3741496 | 12 | 75,891,253 | C | 0.535 | 0.436 | rs3741496 | 2 | 1.49 | (1.24–1.78) | 1.15X10-05 | KRR1 | 3.50X10-05 |
| rs1051446 | 12 | 75,894,114 | C | 0.533 | 0.437 | rs3741496 | 2 | 1.47 | (1.23–1.76) | 1.77X10-05 | KRR1 | 3.50X10-05 |
| rs2447097 | 17 | 2,278,064 | A | 0.351 | 0.261 | rs2447097 | 15 | 1.53 | (1.27–1.85) | 9.45X10-06 | MNT | 8.03X10-04 |
| rs2447095 | 17 | 2,293,420 | A | 0.344 | 0.257 | rs2447097 | 15 | 1.52 | (1.26–1.84) | 1.45X10-05 | MNT | 8.03X10-04 |
| rs12479663 | 20 | 52,708,752 | G | 0.146 | 0.087 | - | 1.81 | (1.38–2.36) | 1.08X10-05 | BCAS1/CYP24A1 | 3.05X10-02 |
a The nearby gene is within 100 kb away