Table 1.
Included cohorts with sample size and numbers of end point events
| Cohort | Country | Total number with two ultrasound scans | Number of subjects with diabetes without previous CVD events | Mean interval between the two ultrasound scans (years) | Mean duration of clinical follow-up after the second ultrasound scan (years) | Number of combined end point events among subjects with diabetes | Crude event rate of the combined end point among subjects with diabetes (per 1,000 person-years) |
|---|---|---|---|---|---|---|---|
| AIR (25) | Sweden | 297 | 12 | 3.3 | 5.1 | 1 | 16.2 |
| ARIC (26) | U.S. | 12,221 | 1,131 | 2.9 | 7.4 | 281 | 33.5 |
| BHS (27) | U.S. | 554 | 22 | 2.4 | 4.3 | 2* | 21.2* |
| Bruneck (28) | Italy | 633 | 47 | 5.0 | 8.0 | 11 | 29.3 |
| CAPS (22) | Germany | 3,284 | 74 | 3.1 | 5.2 | 6 | 15.7 |
| CCCC (29) | Taiwan | 1,285 | 127 | 5.1 | 7.2 | 8 | 8.7 |
| CHS1 (30) | U.S. | 3,551 | 896 | 2.9 | 8.3 | 348 | 46.9 |
| CHS2 (30) | U.S. | 297 | 87 | 5.9 | 5.2 | 25 | 55.5 |
| CMCS (31) | China | 920 | 57 | 5.4 | 4.9 | 2 | 7.2 |
| DIWA (20) | Sweden | 418 | 40 | 5.5 | 2.1 | 2 | 23.4 |
| EAS (32) | U.K. | 620 | 31 | 6.5 | 5.2 | 4 | 25.0 |
| EPICARDIAN (33) | Spain | 161 | 7 | 3.0 | 6.6 | 1 | 21.5 |
| EVA (34) | France | 922 | 57 | 2.0 | 13.2 | 19* | 25.3* |
| INVADE (35) | Germany | 2,534 | 488 | 2.2 | 3.9 | 70 | 36.6 |
| KIHD (36) | Finland | 891 | 29 | 4.1 | 11.5 | 18 | 54.1 |
| NOMAS/INVEST (37) | U.S. | 647 | 116 | 3.6 | 2.9 | 5 | 14.8 |
| PIVUS (38) | Sweden | 680 | 53 | 5.1 | 1.8 | 4* | 40.8* |
| PLIC (39) | Italy | 1,538 | 71 | 2.3 | 4.0 | 1 | 3.5 |
| Rotterdam (40) | The Netherlands | 2,610 | 158 | 6.4 | 5.4 | 51 | 59.5 |
| SAPHIR (41) | Austria | 1,154 | 35 | 4.6 | 9.5 | 1 | 3.0 |
| SHIP (42) | Germany | 1,751 | 283 | 5.2 | 5.5 | 50 | 32.0 |
| Tromsø (43) | Norway | 4,003 | 81 | 6.3 | 6.4 | 25 | 48.1 |
*Number of deaths among subjects with diabetes. AIR, Atherosclerosis and Insulin Resistance study; ARIC, Atherosclerosis Risk In Communities study; BHS, Bogalusa Heart Study; Bruneck, Bruneck study; CAPS, Carotid Atherosclerosis Progression Study; CCCC, Chin-Shan Community Cardiovascular Cohort; CMCS, Chinese Multi-provincial Cohort Study; DIWA, Diabetes, Impaired glucose tolerance in Women and Atherosclerosis; EAS, Edinburgh Artery Study; EPICARDIAN, Estudio epidemiológico sobre enfermedades y factores de riesgo cardiovasculares en ancianos españoles; KIHD, Kuopio Ischaemic Heart Disease study; PIVUS, Prospective Investigation of the Vasculature in Uppsala Seniors; PLIC, Progression of Lesions in the Intima of the Carotid; Rotterdam, Rotterdam Study; SAPHIR, Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk; Tromsø, Tromsø Study.