Table 2.
Average mean CCA-IMT and average annual mean CCA-IMT progression in people with and without diabetes
| Average mean CCA-IMT (mm) |
Average annual mean CCA-IMT progression (mm/year) |
|||||
|---|---|---|---|---|---|---|
| Cohort | Diabetes, mean (SD) | No diabetes, mean (SD) | Difference, mean (SE)& | Diabetes, mean (SD) | No diabetes, mean (SD) | Difference, mean (SE)& |
| AIR | 0.86 (0.14) | 0.79 (0.12) | 0.066 (0.036) | −0.004 (0.040) | 0.001 (0.028) | −0.005 (0.008) |
| ARIC | 0.72 (0.13) | 0.56 (0.11) | 0.052 (0.003) | 0.009 (0.048) | 0.011 (0.037) | −0.001 (0.001) |
| CAPS | 0.81 (0.13) | 0.73 (0.17) | 0.018 (0.018) | −0.004 (0.035) | 0.003 (0.092) | −0.007 (0.011) |
| CHS1 | 0.90 (0.16) | 0.86 (0.14) | 0.038 (0.005) | 0.006 (0.053) | 0.005 (0.045) | 0.001 (0.002) |
| CHS2 | 0.94 (0.15) | 0.92 (0.16) | 0.015 (0.020) | 0.005 (0.030) | 0.011 (0.028) | −0.007 (0.004) |
| CMCS | 0.85 (0.23) | 0.81 (0.19) | 0.040 (0.025) | 0.037 (0.044) | 0.040 (0.041) | −0.002 (0.006) |
| DIWA | 0.94 (0.17) | 0.86 (0.15) | 0.074 (0.025) | −0.001 (0.022) | 0.004 (0.020) | −0.005 (0.003) |
| EAS | 0.87 (0.20) | 0.85 (0.19) | 0.005 (0.033) | 0.030 (0.032) | 0.030 (0.045) | 0.001 (0.008) |
| EPICARDIAN | 0.78 (0.15) | 0.79 (0.21) | −0.004 (0.079) | −0.093 (0.101) | −0.099 (0.133) | 0.001 (0.052) |
| EVA | 0.72 (0.11) | 0.66 (0.10) | 0.045 (0.014) | 0.008 (0.040) | 0.006 (0.046) | 0.002 (0.006) |
| INVADE | 0.86 (0.18) | 0.81 (0.17) | 0.031 (0.008) | 0.012 (0.082) | 0.009 (0.075) | 0.004 (0.004) |
| KIHD | 0.83 (0.12) | 0.81 (0.16) | 0.010 (0.027) | 0.024 (0.022) | 0.028 (0.033) | −0.005 (0.006) |
| NOMAS/INVEST | 0.72 (0.09) | 0.73 (0.08) | −0.005 (0.008) | 0.007 (0.028) | 0.009 (0.030) | −0.002 (0.003) |
| PIVUS | 0.97 (0.17) | 0.92 (0.14) | 0.049 (0.021) | 0.009 (0.034) | 0.009 (0.029) | 0.000 (0.004) |
| PLIC | 0.74 (0.12) | 0.66 (0.13) | 0.029 (0.013) | 0.009 (0.032) | 0.015 (0.036) | −0.007 (0.004) |
| Rotterdam | 0.86 (0.15) | 0.79 (0.14) | 0.046 (0.011) | 0.012 (0.024) | 0.012 (0.021) | 0.000 (0.002) |
| SAPHIR | 0.91 (0.11) | 0.80 (0.12) | 0.074 (0.019) | 0.024 (0.024) | 0.017 (0.019) | 0.005 (0.003) |
| SHIP | 0.83 (0.16) | 0.78 (0.14) | 0.031 (0.009) | 0.009 (0.037) | 0.003 (0.023) | 0.001 (0.002) |
| Tromsø | 0.87 (0.16) | 0.78 (0.14) | 0.053 (0.013) | 0.010 (0.034) | 0.004 (0.019) | 0.006 (0.002) |
| Combined (95% CI)* | 0.82 (0.17) | 0.71 (0.18) | 0.041 (0.036–0.045) | 0.009 (0.052) | 0.010 (0.047) | −0.000 (−0.001 to 0.001) |
Mean CCA-IMT is not available in Bogalusa Heart Study (BHS), Bruneck study (Bruneck), or the Chin-Shan Community Cardiovascular Cohort (CCCC). AIR, Atherosclerosis and Insulin Resistance study; CMCS, Chinese Multi-provincial Cohort Study; DIWA, Diabetes, Impaired glucose tolerance in Women and Atherosclerosis; EAS, Edinburgh Artery Study; EPICARDIAN, Estudio epidemiológico sobre enfermedades y factores de riesgo cardiovasculares en ancianos españoles; KIHD, Kuopio Ischaemic Heart Disease study; PIVUS, Prospective Investigation of the Vasculature in Uppsala Seniors; PLIC, Progression of Lesions in the Intima of the Carotid; Rotterdam, Rotterdam Study; SAPHIR, Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk; Tromsø, Tromsø Study.
&Adjusted for age and sex by multiple regression.
*Combined means and SDs weighted by sample size; differences between people with and without diabetes combined by random-effects meta-analysis.