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. Author manuscript; available in PMC: 2016 Aug 14.
Published in final edited form as: Biochem Biophys Res Commun. 2015 Jun 23;464(1):221–228. doi: 10.1016/j.bbrc.2015.06.120

Figure 4. Niclosamide inhibits multiple oncogenic signaling molecules.

Figure 4

A) Immunoblot of MT-2 and MT-4 cells treated with niclosamide. B) Total protein lysates from (A) were examined with anti-Bcl-2, -Bcl-xL and -Mcl-1 immunoblot. C) MT-2 and MT-4 cells were treated with niclosamideand the cellular protein extracts harvested at indicated time points were examined with immunoblot. D) Total protein lysates from (A) were examined with anti-p-ERK1/2 and anti-ERK1 immunoblot. E) Total protein lysates from (A) were examined with anit-Stat3 immunoblot. F) MT-4 cells were treated with 10 μM of niclosamide, and the nuclear extracts from indicated time points were examined with Stat3 probe EMSA. Oct-1 was used for control.